pharmacokinetics of ceftriaxone in buffalo calves (bubalus bubalis) following intravenous and intramuscular administration

نویسندگان

p. v. gohil

u. d patel

s. k. bhavsar

a. m. thaker

چکیده

pharmacokinetics of ceftriaxone was studied in buffalo calves (bubalus bubalis) after single intravenousand intramuscular administration of 10 mg/kg body weight. the drug concentrations in plasma samples weremeasured by high performance liquid chromatography with uv detection. following intravenousadministration, the drug was rapidly distributed (cpo: 106.5 ± 9.64 μg/ml; t1/2α: 0.09 ± 0.01 h; vdarea: 0.48 ± 0.05 l/kg) and eliminated (t1/2β: 1.27 ± 0.04 h) from the body with a clearance rate of 4.40 ± 0.44 ml/min.kg. following intramuscular administration, the peak plasma concentration of the drug was 15.8 ± 2.4 μg/ml at 0.5 h and the drug was detected up to 12 h. the drug was rapidly absorbed from the site of injection (t1/2ka: 0.35 ± 0.01 h), widely distributed (vdarea: 1.53 ± 0.2 l/kg) and slowly eliminated from the body (t1/2β: 4.38 ± 0.4 h; clb: 4.01 ± 0.30 ml/min.kg). the bioavailability of ceftriaxone was 70.2 ± 2.0% following intramuscular injection. intramuscular injection of ceftriaxone has favourable pharmacokinetics and moderate bioavailability in buffalo calves and can be used for susceptible infections in calves.

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عنوان ژورنال:
iranian journal of veterinary research

ناشر: shiraz university

ISSN 1728-1997

دوره 10

شماره 1 2009

میزبانی شده توسط پلتفرم ابری doprax.com

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